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Article

Human tumor mutants in the p110alpha subunit of PI3K.

Cell cycle (Georgetown, Tex.) - 1 Apr 2006

Liu Zhenning, Roberts Thomas M

Abstract excerpt

The PI3K-Akt pathway is frequently upregulated in human tumors. Recently, somatic mutations of PIK3CA, encoding p110alpha catalytic subunit of Class IA PI3Ks, have been found in various cancers. The two most common types of p110alpha mutants, those in the helical and kinase domains, have been shown to be very potent in Akt activation and oncogenic transformation by several groups. Notably these common mutations...

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PMID: 16627990
DOI: 10.4161/cc.5.7.2605

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