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Article

Concurrent hypermethylation of DNMT1, MGMT and EGFR genes in progression of gliomas.

Diagnostic pathology - 20 Jan 2012

Gömöri Eva, Pál József, Kovács Bernadett, Dóczi Tamás

Abstract excerpt

BACKGROUND: Gliomas are the most common neoplasm of the brain. High-grade gliomas often resist treatment even with aggressive surgical resection and adjuvant radiation and chemotherapy. Despite the combined treatment, they frequently recur with the same or higher-grade histology. Genetic instability is commonly associated with inactivation of the normal DNA repair function and tumour suppressor genes as well as...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22264301
DOI: 10.1186/1746-1596-7-8
PMCID: PMC3292961

Genes

EGFR
MGMT
DNMT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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