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<i>O6-Methylguanine-DNA Methyltransferase</i> Regulation by p53 in Astrocytic Cells

15 Jan 2007

Abstract excerpt

Methylation of the O6-methylguanine-DNA methyltransferase (MGMT) gene promoter (i.e., gene silencing) occurs in 40% to 50% of patients with glioblastoma and predicts benefit from temozolomide chemotherapy; when unmethylated, MGMT repairs DNA damage induced by temozolomide, contributing to chemoresistance. In this study, we tested the hypothesis that MGMT is regulated by p53 in astrocytic cells, the precursors of...

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PMID: 17234766
DOI: 10.1158/0008-5472.can-06-2782

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