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Article

Aberrant hypermethylation of p14ARF and O6-methylguanine-DNA methyltransferase genes in astrocytoma progression.

Brain pathology (Zurich, Switzerland) - 1 Jan 2007

Watanabe Takao, Katayama Yoichi, Yoshino Atsuo, Yachi Kazunari, Ohta Takashi, Ogino Akiyoshi, Komine Chiaki, Fukushima Takao

Abstract excerpt

The aim of the present study was to elucidate genetic alterations that are critically involved in astrocytoma progression. We characterized 27 World Health Organization grade II fibrillary astrocytomas which later underwent recurrence or progression, paying specific attention to the CpG island methylation status of critical growth regulatory genes. p14(ARF) and O(6)-methylguanine-DNA methyltransferase (MGMT)...

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Source

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Identifiers

PMID: 17493032
DOI: 10.1111/j.1750-3639.2006.00030.x
PMCID: PMC8095625

Genes

MGMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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