Article
Lynch Syndrome: Its Impact on Urothelial Carcinoma.
International journal of molecular sciences - 7 Jan 2021
Lindner Andrea Katharina, Schachtner Gert, Tulchiner Gennadi, Thurnher Martin, Untergasser Gerold, Obrist Peter, Pipp Iris, Steinkohl Fabian, Horninger Wolfgang, Culig Zoran, Pichler Renate
Abstract excerpt
Lynch syndrome, known as hereditary nonpolyposis colorectal cancer (HNPCC), is an autosomal-dominant familial cancer syndrome with an increased risk for urothelial cancer (UC). Mismatch repair (MMR) deficiency, due to pathogenic variants in MLH1, MSH2, MSH6, and PMS2, and microsatellite instability, are known for development of Lynch syndrome (LS) associated carcinogenesis. UC is the third most common cancer type...
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