Article
Risks of less common cancers in proven mutation carriers with lynch syndrome.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 10 Dec 2012
Engel Christoph, Loeffler Markus, Steinke Verena, Rahner Nils, Holinski-Feder Elke, Dietmaier Wolfgang, Schackert Hans K, Goergens Heike, von Knebel Doeberitz Magnus, Goecke Timm O, Schmiegel Wolff, Buettner Reinhard, Moeslein Gabriela, Letteboer Tom G W, Gómez García Encarna, Hes Frederik J, Hoogerbrugge Nicoline, Menko Fred H, van Os Theo A M, Sijmons Rolf H, Wagner Anja, Kluijt Irma, Propping Peter, Vasen Hans F A
Abstract excerpt
PURPOSE: Patients with Lynch syndrome are at high risk for colon and endometrial cancer, but also at an elevated risk for other less common cancers. The purpose of this retrospective cohort study was to provide risk estimates for these less common cancers in proven carriers of pathogenic mutations in the mismatch repair (MMR) genes MLH1, MSH2, and MSH6. PATIENTS AND METHODS: Data were pooled from the German and...
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