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Article

Catechol-O-methyltransferase Val158Met polymorphism and negative symptoms after acute antipsychotic treatment in first-episode non-affective psychosis.

Psychiatry research - 30 Jan 2011

Pelayo-Terán José María, Pérez-Iglesias Rocío, Vázquez-Bourgon Javier, Mata Ignacio, Carrasco-Marín Eugenio, Vázquez-Barquero José Luis, Crespo-Facorro Benedicto

Abstract excerpt

Genetic factors play an important role in the understanding of clinical response to antipsychotic treatments. We aimed to assess the effect of the catechol-O-methyltransferase (COMT) genotype in the short-term (6 weeks) clinical response of 161 first-episode psychosis patients. COMT genotype was not related to clinical response at 6 weeks. Val homozygote patients showed higher negative symptoms than Met...

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Identifiers

PMID: 20591499
DOI: 10.1016/j.psychres.2010.06.006

Genes

COMT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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