Article
Molecular and functional expression of multidrug resistance-associated protein-1 in primary cultured rat alveolar epithelial cells.
Journal of pharmaceutical sciences - 1 Jun 2008
Patel Leena N, Uchiyama Tomomi, Kim Kwang-Jin, Borok Zea, Crandall Edward D, Shen Wei-Chiang, Lee Vincent H L
Abstract excerpt
Multidrug resistance-associated protein-1 (MRP1) is an integral membrane efflux protein that is implicated in multidrug resistance in cancer, but it is also expressed in normal tissues. The objective of this study was to determine the expression, localization and functional activity of MRP1 in primary cultured rat alveolar epithelial cells of types I- and II cell-like phenotypes. RT-PCR data showed 550-base pair...
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