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Article

Multidrug resistance gene G1199A polymorphism alters efflux transport activity of P-glycoprotein.

The Journal of pharmacology and experimental therapeutics - 1 Sept 2004

Woodahl Erica L, Yang Ziping, Bui Tot, Shen Danny D, Ho Rodney J Y

Abstract excerpt

The significance of the human multidrug resistance gene (MDR1) G1199A polymorphism, resulting in a Ser400Asn modification in P-glycoprotein (P-gp), remains unclear. We have developed stable recombinant LLC-PK1 epithelial cells expressing either MDR1wt or MDR11199 to evaluate functional consequences of G1199A...

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Share to Antineoplastic Agents
Share to ATP Binding Cassette Transporter, Subfamily B, Member 1
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Drug Resistance, Neoplasm

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Source

Identifiers

PMID: 15100388
DOI: 10.1124/jpet.104.065383

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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