Sign Epistasis Can be Absent in Multi-peaked Landscapes With Neutral Mutations.

Abstract excerpt

Fitness landscapes provide a rigorous mathematical framework for analyzing evolutionary dynamics, including the study of epistasis, the main obstacle to predicting phenotype from genotype. In 2011, Poelwijk et al. formulated a foundational theorem stating that in any multi-peaked fitness landscape, "at least two mutations exhibit reciprocal sign epistasis" (Poelwijk et al., J. Theor. Biol., 272:141). The proof...

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• Epistasis, Genetic
• Evolution, Molecular
• Genetic Fitness
• Genotype
• Models, Genetic
• Mutation