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Article

Monte Carlo study of the formation and conformational properties of dimers of Aβ42 variants.

Journal of molecular biology - 8 Jul 2011

Mitternacht Simon, Staneva Iskra, Härd Torleif, Irbäck Anders

Abstract excerpt

Small soluble oligomers, and dimers in particular, of the amyloid β-peptide (Aβ) are believed to play an important pathological role in Alzheimer's disease. Here, we investigate the spontaneous dimerization of Aβ42, with 42 residues, by implicit solvent all-atom Monte Carlo simulations, for the wild-type peptide and the mutants F20E, E22G and E22G/I31E. The observed dimers of these variants share many overall...

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Identifiers

PMID: 21616081
DOI: 10.1016/j.jmb.2011.05.014

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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