Article
Haplotype and cell proliferation analyses of candidate lung cancer susceptibility genes on chromosome 15q24-25.1.
Cancer research - 1 Oct 2009
Liu Yan, Liu Pengyuan, Wen Weidong, James Michael A, Wang Yian, Bailey-Wilson Joan E, Amos Christopher I, Pinney Susan M, Yang Ping, de Andrade Mariza, Petersen Gloria M, Wiest Jonathan S, Fain Pamela R, Schwartz Ann G, Gazdar Adi, Gaba Colette, Rothschild Henry, Mandal Diptasri, Kupert Elena, Lee Juwon, Seminara Daniela, Minna John, Anderson Marshall W, You Ming
Abstract excerpt
Recent genome-wide association studies have linked the chromosome 15q24-25.1 locus to nicotine addiction and lung cancer susceptibility. To refine the 15q24-25.1 locus, we performed a haplotype-based association analysis of 194 familial lung cases and 219 cancer-free controls from the Genetic Epidemiology of Lung Cancer Consortium (GELCC) collection, and used proliferation and apoptosis analyses to determine...
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