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Article

Sumoylation regulates interaction of FOG1 with C-terminal-binding protein (CTBP).

The Journal of biological chemistry - 3 Sept 2010

Snow Jonathan W, Kim Jonghwan, Currie Caroline R, Xu Jian, Orkin Stuart H

Abstract excerpt

Erythropoietic and megakaryocytic programs are specified from multipotential progenitors by the transcription factor GATA1. FOG1, a GATA1-interaction partner, is critical for GATA1 function in several contexts by bringing multiple complexes into association with GATA1 to facilitate activation or repression of target genes. To further elucidate regulation of these associations by cellular and extracellular cues,...

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Source

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Identifiers

PMID: 20587419
DOI: 10.1074/jbc.M109.096909
PMCID: PMC2934671

Genes

GATA1
CTBP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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Sumoylation regulates interaction of FOG1 with C-terminal-binding protein (CTBP).PMID 20587419Read ↗

Controlling hematopoiesis through sumoylation-dependent regulation of a GATA factor.Semantic proximity Read ↗

Distinct domains of the GATA-1 cofactor FOG-1 differentially influence erythroid versus megakaryocytic maturation.Semantic proximity Read ↗

SUMOylation regulates the transcriptional repression activity of FOG-2 and its association with GATA-4.Semantic proximity Read ↗

FOG-1-mediated recruitment of NuRD is required for cell lineage re-enforcement during haematopoiesis.Semantic proximity Read ↗

GATA proteins work together with friend of GATA (FOG) and C-terminal binding protein (CTBP) co-regulators to control adipogenesis.Semantic proximity Read ↗

Interaction between FOG-1 and the corepressor C-terminal binding protein is dispensable for normal erythropoiesis in vivo.Semantic proximity Read ↗

The N termini of Friend of GATA (FOG) proteins define a novel transcriptional repression motif and a superfamily of transcriptional repressors.Semantic proximity Read ↗

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Friend of GATA-1-independent transcriptional repression: a novel mode of GATA-1 function.Semantic proximity Read ↗

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