Article
Phenotypic characterization of human colorectal cancer stem cells.
Proceedings of the National Academy of Sciences of the United States of America - 12 Jun 2007
Dalerba Piero, Dylla Scott J, Park In-Kyung, Liu Rui, Wang Xinhao, Cho Robert W, Hoey Timothy, Gurney Austin, Huang Emina H, Simeone Diane M, Shelton Andrew A, Parmiani Giorgio, Castelli Chiara, Clarke Michael F
Abstract excerpt
Recent observations indicate that, in several types of human cancer, only a phenotypic subset of cancer cells within each tumor is capable of initiating tumor growth. This functional subset of cancer cells is operationally defined as the "cancer stem cell" (CSC) subset. Here we developed a CSC model for the study of human colorectal cancer (CRC). Solid CRC tissues, either primary tissues collected from surgical...
Topics
- Activated-Leukocyte Cell Adhesion Molecule
- Animals
- Antigens, Neoplasm
- Biomarkers, Tumor
- Cell Separation
- Colorectal Neoplasms
- Epithelial Cells
- Flow Cytometry
- Humans