Article
Spatial normalization improves the quality of genotype calling for Affymetrix SNP 6.0 arrays.
BMC bioinformatics - 29 Jun 2010
Chai High Seng, Therneau Terry M, Bailey Kent R, Kocher Jean-Pierre A
Abstract excerpt
BACKGROUND: Microarray measurements are susceptible to a variety of experimental artifacts, some of which give rise to systematic biases that are spatially dependent in a unique way on each chip. It is likely that such artifacts affect many SNP arrays, but the normalization methods used in currently available genotyping algorithms make no attempt at spatial bias correction. Here, we propose an effective...
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