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Spatial normalization of array-CGH data

22 May 2006

Abstract excerpt

BACKGROUND: Array-based comparative genomic hybridization (array-CGH) is a recently developed technique for analyzing changes in DNA copy number. As in all microarray analyses, normalization is required to correct for experimental artifacts while preserving the true biological signal. We investigated various sources of systematic variation in array-CGH data and identified two distinct types of spatial effect of...

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PMID: 16716215
DOI: 10.1186/1471-2105-7-264

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