Article
Impact of genotyping errors on statistical power of association tests in genomic analyses: A case study.
Genetic epidemiology - 1 Feb 2017
Hou Lin, Sun Ning, Mane Shrikant, Sayward Fred, Rajeevan Nallakkandi, Cheung Kei-Hoi, Cho Kelly, Pyarajan Saiju, Aslan Mihaela, Miller Perry, Harvey Philip D, Gaziano J Michael, Concato John, Zhao Hongyu
Abstract excerpt
A key step in genomic studies is to assess high throughput measurements across millions of markers for each participant's DNA, either using microarrays or sequencing techniques. Accurate genotype calling is essential for downstream statistical analysis of genotype-phenotype associations, and next generation sequencing (NGS) has recently become a more common approach in genomic studies. How the accuracy of variant...
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