Article
Genetic markers in acquired haemophilia.
Haemophilia : the official journal of the World Federation of Hemophilia - 1 May 2010
Oldenburg J, Zeitler H, Pavlova A
Abstract excerpt
Acquired haemophilia (AH) is a rare autoimmune bleeding disorder, which arises as a result of the spontaneous production of autoantibodies against endogenous factor VIII. The breakdown in immune tolerance is thought to be a result of a combination of genetic and environmental factors. Both human leucocyte antigen (HLA) and cytotoxic T lymphocyte antigen 4 (CTLA-4) play an important role in the maintenance of...
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