Key Genes of the Immune System and Predisposition to Acquired Hemophilia A: Evidence from a Spanish Cohort of 49 Patients Using Next-Generation Sequencing.

doi:10.3390/ijms242216372

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Article

Key Genes of the Immune System and Predisposition to Acquired Hemophilia A: Evidence from a Spanish Cohort of 49 Patients Using Next-Generation Sequencing.

International journal of molecular sciences - 15 Nov 2023

Pardos-Gea Jose, Martin-Fernandez Laura, Closa Laia, Ferrero Ainara, Marzo Cristina, Rubio-Rivas Manuel, Mitjavila Francesca, González-Porras José Ramón, Bastida José María, Mateo José, Carrasco Marina, Bernardo Ángel, Astigarraga Itziar, Aguinaco Reyes, Corrales Irene, Garcia-Martínez Iris, Vidal Francisco

Abstract excerpt

Acquired hemophilia A (AHA) is a rare bleeding disorder caused by the presence of autoantibodies against factor VIII (FVIII). As with other autoimmune diseases, its etiology is complex and its genetic basis is unknown. The aim of this study was to identify the immunogenetic background that predisposes individuals to AHA. HLA and KIR gene clusters, as well as KLRK1, were sequenced using next-generation sequencing...

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PMID: 38003562
DOI: 10.3390/ijms242216372
PMCID: PMC10671092

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Source receipt: pubmed, retrieved 7 Sept 2026.

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