Article
Topography of tyrosine residues and their involvement in peroxidation of polyunsaturated cardiolipin in cytochrome c/cardiolipin peroxidase complexes.
Biochimica et biophysica acta - 1 Sept 2011
Kapralov Alexandr A, Yanamala Naveena, Tyurina Yulia Y, Castro Laura, Samhan-Arias Alejandro, Vladimirov Yuri A, Maeda Akihiro, Weitz Andrew A, Peterson Jim, Mylnikov Danila, Demicheli Verónica, Tortora Verónica, Klein-Seetharaman Judith, Radi Rafael, Kagan Valerian E
Abstract excerpt
Formation of cytochrome c (cyt c)/cardiolipin (CL) peroxidase complex selective toward peroxidation of polyunsaturated CLs is a pre-requisite for mitochondrial membrane permeabilization. Tyrosine residues - via the generation of tyrosyl radicals (Tyr) - are likely reactive intermediates of the peroxidase cycle leading to CL peroxidation. We used mutants of horse heart cyt c in which each of the four Tyr residues...
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