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Article

Role of primary miRNA polymorphic variants in metastatic colon cancer patients treated with 5-fluorouracil and irinotecan.

The pharmacogenomics journal - 1 Dec 2011

Boni V, Zarate R, Villa J C, Bandrés E, Gomez M A, Maiello E, Garcia-Foncillas J, Aranda E

Abstract excerpt

MicroRNAs are non-coding RNAs that can block mRNA translation and influence mRNA stability. Recent evidence indicates that miRNA variations can affect drug resistance, efficacy, and metabolism, opening new avenues of pharmacogenomics research. We investigated associations between polymorphisms in both miRNA-containing genomic regions (primary and precursor miRNA) and in genes related to miRNA biogenesis with...

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Identifiers

PMID: 20585341
DOI: 10.1038/tpj.2010.58

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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