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Article

Single nucleotide polymorphisms within MicroRNAs, MicroRNA targets, and MicroRNA biogenesis genes and their impact on colorectal cancer survival.

Genes, chromosomes & cancer - 1 Apr 2017

Mullany Lila E, Herrick Jennifer S, Wolff Roger K, Slattery Martha L

Abstract excerpt

We have shown that single nucleotide polymorphisms (SNPs) in microRNA (miRNA) genes, miRNA target genes, and miRNA biogenesis genes minimally contribute to colon cancer risk. It is possible that these SNPs alter survival. We analyzed 565 SNPs in or adjacent to microRNAs, target genes, or biogenesis genes, using 1,115 cases and 1,173 controls; 837 cases had survival information. We tested SNPs for associations...

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Identifiers

PMID: 27859935
DOI: 10.1002/gcc.22434
PMCID: PMC6007859

Genes

ADAMTS1
PRKRA

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