Article
Polymorphisms in microRNA genes as predictors of clinical outcomes in colorectal cancer patients.
Carcinogenesis - 1 Jan 2015
Pardini Barbara, Rosa Fabio, Naccarati Alessio, Vymetalkova Veronika, Ye Yuanqing, Wu Xifeng, di Gaetano Cornelia, Buchler Tomas, Novotny Jan, Matullo Giuseppe, Vodicka Pavel
Abstract excerpt
Colorectal cancer (CRC) is one of the most frequently diagnosed malignancies worldwide. It is routinely cured by a 5-fluorouracil (5-FU)-based chemotherapy which improves outcomes in patients. We investigated the effect of single nucleotide polymorphisms (SNPs) in two microRNA (miRNA)-encoding genes that have been previously reported as important in prognosis in patients with stage III CRC and treated with...
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