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Article

Mitochondrial defects triggered by amg-1 mutation elicit UPRmt and phagocytic clearance during spermatogenesis in C. elegans.

Development (Cambridge, England) - 1 Feb 2024

Wang Peng, Chen Lianwan, Wang Ning, Miao Long, Zhao Yanmei

Abstract excerpt

Mitochondria are the powerhouses of many biological processes. During spermatogenesis, post-transcriptional regulation of mitochondrial gene expression is mediated by nuclear-encoded mitochondrial RNA-binding proteins (mtRBPs). We identified AMG-1 as an mtRBP required for reproductive success in Caenorhabditis elegans. amg-1 mutation led to defects in mitochondrial structure and sperm budding, resulting in...

Topics

Animals
Male
Caenorhabditis elegans
Caenorhabditis elegans Proteins
Semen
Spermatogenesis
Mutation
Mitochondrial Diseases
Adenosine

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38224006
DOI: 10.1242/dev.202165
PMCID: PMC13086458

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-38224006-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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