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Oocyte mitophagy is critical for extended reproductive longevity

20 Sept 2022

Abstract excerpt

Women's reproductive cessation is the earliest sign of human aging and is caused by decreasing oocyte quality. Similarly, C. elegans' reproduction declines in mid-adulthood and is caused by oocyte quality decline. Aberrant mitochondrial morphology is a hallmark of age-related dysfunction, but the role of mitochondrial morphology and dynamics in reproductive aging is unclear. We examined the requirements for...

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PMID: 36126046
DOI: 10.1371/journal.pgen.1010400

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