Article
Genome-wide association study identifies novel loci predisposing to cutaneous melanoma.
Human molecular genetics - 15 Dec 2011
Amos Christopher I, Wang Li-E, Lee Jeffrey E, Gershenwald Jeffrey E, Chen Wei V, Fang Shenying, Kosoy Roman, Zhang Mingfeng, Qureshi Abrar A, Vattathil Selina, Schacherer Christopher W, Gardner Julie M, Wang Yuling, Bishop D Tim, Barrett Jennifer H, MacGregor Stuart, Hayward Nicholas K, Martin Nicholas G, Duffy David L, Mann Graham J, Cust Anne, Hopper John, Brown Kevin M, Grimm Elizabeth A, Xu Yaji, Han Younghun, Jing Kaiyan, McHugh Caitlin, Laurie Cathy C, Doheny Kim F, Pugh Elizabeth W, Seldin Michael F, Han Jiali, Wei Qingyi
Abstract excerpt
We performed a multistage genome-wide association study of melanoma. In a discovery cohort of 1804 melanoma cases and 1026 controls, we identified loci at chromosomes 15q13.1 (HERC2/OCA2 region) and 16q24.3 (MC1R) regions that reached genome-wide significance within this study and also found strong evidence for genetic effects on susceptibility to melanoma from markers on chromosome 9p21.3 in the p16/ARF region...
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