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Article

Telomere shortening in the damaged small bile ducts in primary biliary cirrhosis reflects ongoing cellular senescence†

28 Mar 2008

Abstract excerpt

UNLABELLED: Telomere shortening is a trigger of cellular senescence. Biliary epithelial cells in damaged small bile ducts in primary biliary cirrhosis (PBC) show senescent features such as the expression of senescence-associated beta-galactosidase and the increased expression of p16(INK4a) and p21(WAF1/Cip1). We investigated whether the telomere shortening is involved in the pathogenesis of biliary cellular...

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PMID: 18536059
DOI: 10.1002/hep.22348

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