Delineating electrogenic reactions during lactose/H+ symport.

doi:10.1021/bi100492p

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Article

Delineating electrogenic reactions during lactose/H+ symport.

Biochemistry - 27 Jul 2010

Garcia-Celma Juan J, Ploch Julian, Smirnova Irina, Kaback H Ronald, Fendler Klaus

Abstract excerpt

Electrogenic reactions accompanying downhill lactose/H(+) symport catalyzed by the lactose permease of Escherichia coli (LacY) have been assessed using solid-supported membrane-based electrophysiology with improved time resolution. Rates of charge translocation generated by purified LacY reconstituted into proteoliposomes were analyzed over a pH range from 5.2 to 8.5, which allows characterization of two...

Topics

Binding Sites
Cell Membrane
Electrophysiological Phenomena
Escherichia coli
Escherichia coli Proteins
Hydrogen-Ion Concentration
Lactose
Monosaccharide Transport Proteins
Mutation
Protons
Symporters

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Identifiers

PMID: 20568736
DOI: 10.1021/bi100492p
PMCID: PMC2907097

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