Prognostic impact of isocitrate dehydrogenase enzyme isoforms 1 and 2 mutations in acute myeloid leukemia: a study by the Acute Leukemia French Association group.

doi:10.1200/JCO.2010.28.2285

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Article

Prognostic impact of isocitrate dehydrogenase enzyme isoforms 1 and 2 mutations in acute myeloid leukemia: a study by the Acute Leukemia French Association group.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 10 Aug 2010

Boissel Nicolas, Nibourel Olivier, Renneville Aline, Gardin Claude, Reman Oumedaly, Contentin Nathalie, Bordessoule Dominique, Pautas Cécile, de Revel Thierry, Quesnel Bruno, Huchette Pascal, Philippe Nathalie, Geffroy Sandrine, Terre Christine, Thomas Xavier, Castaigne Sylvie, Dombret Hervé, Preudhomme Claude

Abstract excerpt

PURPOSE: Recently, whole-genome sequencing in acute myeloid leukemia (AML) identified recurrent isocitrate dehydrogenase enzyme isoform (IDH1) mutations (IDH1m), previously reported to be involved in gliomas as well as IDH2 mutations (IDH2m). The prognosis of both IDH1m and IDH2m in AML remains unclear. PATIENTS AND METHODS: The prevalence and the prognostic impact of R132 IDH1 and R172 IDH2 mutations were...

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Identifiers

PMID: 20625116
DOI: 10.1200/JCO.2010.28.2285

Genes

FLT3
IDH1
IDH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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