Article
Retroviral Rem protein requires processing by signal peptidase and retrotranslocation for nuclear function.
Proceedings of the National Academy of Sciences of the United States of America - 6 Jul 2010
Byun Hyewon, Halani Nimita, Mertz Jennifer A, Ali Almas F, Lozano Mary M, Dudley Jaquelin P
Abstract excerpt
Mouse mammary tumor virus (MMTV) is a complex murine retrovirus that encodes an HIV Rev-like export protein, Rem, from a doubly spliced version of envelope (Env) mRNA. Previously, the N-terminal 98-amino acid sequence of Rem, which is identical to Env signal peptide (SP), and full-length Rem were shown to be functional in a reporter assay that measures a postexport function. Here we show that MMTV-infected cells...
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