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Article

Structural basis of suppression of host translation termination by Moloney Murine Leukemia Virus.

Nature communications - 22 Jun 2016

Tang Xuhua, Zhu Yiping, Baker Stacey L, Bowler Matthew W, Chen Benjamin Jieming, Chen Chen, Hogg J Robert, Goff Stephen P, Song Haiwei

Abstract excerpt

Retroviral reverse transcriptase (RT) of Moloney murine leukemia virus (MoMLV) is expressed in the form of a large Gag-Pol precursor protein by suppression of translational termination in which the maximal efficiency of stop codon read-through depends on the interaction between MoMLV RT and peptidyl release factor 1 (eRF1). Here, we report the crystal structure of MoMLV RT in complex with eRF1. The MoMLV RT...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27329342
DOI: 10.1038/ncomms12070
PMCID: PMC4917968

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