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Article

Co-lethality studied as an asset against viral drug escape: the HIV protease case.

Biology direct - 17 Jun 2010

Brouillet Sophie, Valere Thomas, Ollivier Emmanuelle, Marsan Laurent, Vanet Anne

Abstract excerpt

BACKGROUND: Co-lethality, or synthetic lethality is the documented genetic situation where two, separately non-lethal mutations, become lethal when combined in one genome. Each mutation is called a "synthetic lethal" (SL) or a co-lethal. Like invariant positions, SL sets (SL linked couples) are c...

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Identifiers

PMID: 20565756
DOI: 10.1186/1745-6150-5-40
PMCID: PMC2898770

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20565756-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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