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Article

Unusual binding mode of an HIV-1 protease inhibitor explains its potency against multi-drug-resistant virus strains.

Journal of molecular biology - 6 Dec 2002

Weber Jan, Mesters Jeroen R, Lepsík Martin, Prejdová Jana, Svec Martin, Sponarová Jana, Mlcochová Petra, Skalická Kristina, Strísovský Kvido, Uhlíková Tána, Soucek Milan, Machala Ladislav, Stanková Marie, Vondrásek Jirí, Klimkait Thomas, Kraeusslich Hans Georg, Hilgenfeld Rolf, Konvalinka Jan

Abstract excerpt

Protease inhibitors (PIs) are an important class of drugs for the treatment of HIV infection. However, in the course of treatment, resistant viral variants with reduced sensitivity to PIs often emerge and become a major obstacle to successful control of viral load. On the basis of a compound equi...

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Identifiers

PMID: 12460574
DOI: 10.1016/s0022-2836(02)01139-7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-12460574-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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