Article
Methods for optimizing antiviral combination therapies.
Bioinformatics (Oxford, England) - 1 Jan 2003
Beerenwinkel Niko, Lengauer Thomas, Däumer Martin, Kaiser Rolf, Walter Hauke, Korn Klaus, Hoffmann Daniel, Selbig Joachim
Abstract excerpt
MOTIVATION: Despite some progress with antiretroviral combination therapies, therapeutic success in the management of HIV-infected patients is limited. The evolution of drug-resistant genetic variants in response to therapy plays a key role in treatment failure and finding a new potent drug combination after therapy failure is considered challenging. RESULTS: To estimate the activity of a drug combination against...
Topics
- Algorithms
- Anti-HIV Agents
- Artificial Intelligence
- Cluster Analysis
- Computing Methodologies
- DNA, Viral
- Drug Combinations
- Drug Resistance, Viral
- Drug Therapy, Computer-Assisted
- Gene Expression Profiling
- Genome, Viral
- HIV
- HIV Infections