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Article

Methods for optimizing antiviral combination therapies.

Bioinformatics (Oxford, England) - 1 Jan 2003

Beerenwinkel Niko, Lengauer Thomas, Däumer Martin, Kaiser Rolf, Walter Hauke, Korn Klaus, Hoffmann Daniel, Selbig Joachim

Abstract excerpt

MOTIVATION: Despite some progress with antiretroviral combination therapies, therapeutic success in the management of HIV-infected patients is limited. The evolution of drug-resistant genetic variants in response to therapy plays a key role in treatment failure and finding a new potent drug combination after therapy failure is considered challenging. RESULTS: To estimate the activity of a drug combination against...

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Identifiers

PMID: 12855433
DOI: 10.1093/bioinformatics/btg1001

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