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Article

Whole-Exome Sequencing Identifies a Novel TRPM4 Mutation in a Chinese Family with Atrioventricular Block.

BioMed research international - 1 Jan 2021

Dong Yi, Du Ran, Fan Liang-Liang, Jin Jie-Yuan, Huang Hao, Chen Ya-Qin, Bi Dan-Dong, Xiang Rong

Abstract excerpt

Atrioventricular block (AVB) is a leading cause of sudden cardiac death, and most of AVB cases are presented as autosomal dominant. The electrocardiogram of AVB patients presents an abnormal progressive cardiac conduction disorder between atria and ventricles. Transient receptor potential melastatin 4 (TRPM4) is a nonselective Ca2+-activated cation channel gene defined as a novel disease-causing gene of AVB. So...

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Identifiers

PMID: 33959666
DOI: 10.1155/2021/9247541
PMCID: PMC8075657

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