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Article

The Role of TRPM4 Gene Mutations in Causing Familial Progressive Cardiac Conduction Disease: A Further Contribution.

Genes - 28 Jan 2022

Palladino Alberto, Papa Andrea Antonio, Petillo Roberta, Scutifero Marianna, Morra Salvatore, Passamano Luigia, Nigro Vincenzo, Politano Luisa

Abstract excerpt

Progressive cardiac conduction disease (PCCD) is a relatively common condition in young and elderly populations, related to rare mutations in several genes, including SCN5A, SCN1B, LMNA and GJA5, TRPM4. Familial cases have also been reported. We describe a family with a large number of individuals necessitating pacemaker implantation, likely due to varying degrees of PCCD. The proband is a 47-year-old-patient,...

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Identifiers

PMID: 35205305
DOI: 10.3390/genes13020258
PMCID: PMC8871839

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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