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Article

TRPV4 channels augment macrophage activation and ventilator-induced lung injury.

American journal of physiology. Lung cellular and molecular physiology - 1 Sept 2010

Hamanaka Kazutoshi, Jian Ming-Yuan, Townsley Mary I, King Judy A, Liedtke Wolfgang, Weber David S, Eyal Fabien G, Clapp Mary M, Parker James C

Abstract excerpt

We have previously implicated transient receptor potential vanilloid 4 (TRPV4) channels and alveolar macrophages in initiating the permeability increase in response to high peak inflation pressure (PIP) ventilation. Alveolar macrophages were harvested from TRPV4(-/-) and TRPV4(+/+) mice and instilled in the lungs of mice of the opposite genotype. Filtration coefficients (K(f)) measured in isolated perfused lungs...

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Share to Macrophage Activation
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 20562229
DOI: 10.1152/ajplung.00315.2009
PMCID: PMC2951075

Genes

TRPV4
PIP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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