Article
PACSINs bind to the TRPV4 cation channel. PACSIN 3 modulates the subcellular localization of TRPV4.
The Journal of biological chemistry - 7 Jul 2006
Cuajungco Math P, Grimm Christian, Oshima Kazuo, D'hoedt Dieter, Nilius Bernd, Mensenkamp Arjen R, Bindels René J M, Plomann Markus, Heller Stefan
Abstract excerpt
TRPV4 is a cation channel that responds to a variety of stimuli including mechanical forces, temperature, and ligand binding. We set out to identify TRPV4-interacting proteins by performing yeast two-hybrid screens, and we isolated with the avian TRPV4 amino terminus the chicken orthologues of mammalian PACSINs 1 and 3. The PACSINs are a protein family consisting of three members that have been implicated in...
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