Article
Transmission of human immunodeficiency virus I drug resistance - a case report. What are the clinical implications?
European journal of medical research - 18 May 2010
Anadol E, Kaiser R, Verheyen J, Schülter E, Emmelkamp J, Schwarze-Zander C, Kupfer B, Wasmuth J C, Rockstroh J K
Abstract excerpt
The success of first-line antiretroviral therapy can be challenged by the acquisition of primary drug resistance. Here we report a case where baseline genotypic resistance testing detected resistance conferring nucleoside/nucleotide reverse transcriptase inhibitor (NRTI)-associated mutations, but no primary mutations for protease inhibitor (PI). Subsequent PI-based HAART with boosted saquinavir led to virological...
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