Article
Melting point assay for the JAK2 V617F mutation, comparison with amplification refractory mutation system (ARMS) in diagnostic samples, and implications for daily routine.
Molecular diagnosis & therapy - 1 Jun 2010
Ochsenreither Sebastian, Reinwald Mark, Thiel Eckhard, Burmeister Thomas
Abstract excerpt
BACKGROUND: Reliable detection of the JAK2 V617F mutation is a major criterion in the diagnosis of BCR/ABL-negative myeloproliferative neoplasms such as polycythemia vera, essential thrombocythemia, and primary myelofibrosis. A multitude of methods has been applied to both qualitative and quantitative assessment of the mutational status of patients, without defining a gold standard for the daily diagnostic...
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