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Article

Validating the Sensitivity of High-Resolution Melting Analysis for JAK2 V617F Mutation in the Clinical Setting.

Journal of clinical laboratory analysis - 1 Nov 2016

Lin Chien-Yu, Ho Cheng-Mao, Tamamyan Gevorg, Yang Shu-Fen, Peng Ching-Tien, Chang Jan-Gowth

Abstract excerpt

BACKGROUND: Janus kinase 2 (JAK2) plays an important role in normal hematopoietic growth factor signaling. The detection of the JAK2 V617F mutation (c.1849GNT, GTC → TTC) is crucial for the diagnosis of myeloproliferative neoplasm (MPN) and has become the essential criteria for diagnosis of MPN by the WHO. High-resolution melt (HRM) curve analysis is a nongel-based, closed-tube method, in which PCR amplification...

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Identifiers

PMID: 27169616
DOI: 10.1002/jcla.21945
PMCID: PMC6807203

Genes

JAK2

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Validating the Sensitivity of High-Resolution Melting Analysis for JAK2 V617F Mutation in the Clinical Setting.PMID 27169616Read ↗

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