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Article

Human APOE isoform-dependent effects on brain beta-amyloid levels in PDAPP transgenic mice.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 27 May 2009

Bales Kelly R, Liu Feng, Wu Su, Lin Suizhen, Koger Deanna, DeLong Cynthia, Hansen Jeffrey C, Sullivan Patrick M, Paul Steven M

Abstract excerpt

To investigate the role of human apolipoprotein E (apoE) on Abeta deposition in vivo, we crossed PDAPP mice lacking mouse Apoe to targeted replacement mice expressing human apoE (PDAPP/TRE2, PDAPP/TRE3, or PDAPP/TRE4). We then measured the levels of apoE protein and Abeta peptides in plasma, CSF, and brain homogenates in these mice at different ages. We also quantified the amount of brain Abeta and amyloid burden...

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Source

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Identifiers

PMID: 19474305
DOI: 10.1523/JNEUROSCI.0887-09.2009
PMCID: PMC6665579

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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