Article
ApoE and clusterin cooperatively suppress Abeta levels and deposition: evidence that ApoE regulates extracellular Abeta metabolism in vivo.
Neuron - 22 Jan 2004
DeMattos Ronald B, Cirrito John R, Parsadanian Maia, May Patrick C, O'Dell Mark A, Taylor Jennie W, Harmony Judith A K, Aronow Bruce J, Bales Kelly R, Paul Steven M, Holtzman David M
Abstract excerpt
Apolipoprotein E (apoE) and clusterin can influence structure, toxicity, and accumulation of the amyloid-beta (Abeta) peptide in brain. Both molecules may also be involved in Abeta metabolism prior to its deposition. To assess this possibility, we compared PDAPP transgenic mice that develop age-dependent Abeta accumulation in the absence of apoE or clusterin as well as in the absence of both proteins. apoE(-/-)...
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