Article
Evaluation of five interleukin genes for association with end-stage renal disease in white Europeans.
American journal of nephrology - 1 Jan 2010
Buckham Theresa A, McKnight Amy Jayne, Benevente David, Courtney Aisling E, Patterson Christopher C, Simmonds Matt, Gough Steven, Middleton Derek, Borrows Richard, Maxwell Alexander P
Abstract excerpt
BACKGROUND: Genetic variation within interleukin genes has been reported to be associated with end-stage renal disease (ESRD). These findings have not been consistently replicated. No study has yet reported the comprehensive investigation of IL1A, IL1B, IL1RN,IL6 and IL10 genes. METHODS: 664 kidney transplant recipients (cases) and 577 kidney donors (controls) were genotyped to establish if common variants in...
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