Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Endothelial SUR‐8 acts in an ERK‐independent pathway during atrioventricular cushion development

14 Jun 2010

Abstract excerpt

SUR-8, a conserved leucine-rich repeats protein, was first identified as a positive regulator of Ras pathway in Caenorhabditis elegans. Biochemical studies indicated that SUR-8 interacts with Ras and Raf, leading to the elevated ERK activity. However, the physiological role of SUR-8 during mammalian development remains unclear. Here we found that germline deletion of SUR-8 in mice resulted in early embryonic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cardiac Fibrosis and Remodeling
Share to Congenital heart defects research
Share to Tissue Engineering and Regenerative Medicine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 20549726
DOI: 10.1002/dvdy.22343

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Endothelial SUR‐8 acts in an ERK‐independent pathway during atrioventricular cushion developmentPMID 20549726Read ↗

ERp44 is Required for Endocardial Cushion Development by Regulating VEGFA Secretion in MyocardiumSemantic proximity Read ↗

SUR-8, a conserved Ras-binding protein with leucine-rich repeats, positively regulates Ras-mediated signaling in C. elegans.Semantic proximity Read ↗

Endothelial‐to‐mesenchymal transition in cardiovascular diseases: Developmental signaling pathways gone awrySemantic proximity Read ↗

FRS2α-dependent cell fate transition during endocardial cushion morphogenesis.Semantic proximity Read ↗

Loss of Apela Peptide in Mice Causes Low Penetrance Embryonic Lethality and Defects in Early Mesodermal Derivatives.Semantic proximity Read ↗

A lin-45 raf enhancer screen identifies eor-1, eor-2 and unusual alleles of Ras pathway genes in Caenorhabditis elegans.Semantic proximity Read ↗

Experimental studies on the spatiotemporal expression of WT1 and RALDH2 in the embryonic avian heart: a model for the regulation of myocardial and valvuloseptal development by epicardially derived cells (EPDCs).Semantic proximity Read ↗

Role of ERK1/2 signaling in congenital valve malformations in Noonan syndrome.Semantic proximity Read ↗

Atrioventricular cushion transformation is mediated by ALK2 in the developing mouse heartSemantic proximity Read ↗

Endothelial ERK signaling controls lymphatic fate specificationSemantic proximity Read ↗

Mmp15 is a direct target of Snai1 during endothelial to mesenchymal transformation and endocardial cushion developmentSemantic proximity Read ↗

Genetic and cellular analyses of zebrafish atrioventricular cushion and valve developmentSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.