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Article

Role of ERK1/2 signaling in congenital valve malformations in Noonan syndrome.

Proceedings of the National Academy of Sciences of the United States of America - 2 Dec 2008

Krenz Maike, Gulick James, Osinska Hanna E, Colbert Melissa C, Molkentin Jeffery D, Robbins Jeffrey

Abstract excerpt

Noonan syndrome (NS) is the most common nonchromosomal genetic disorder associated with cardiovascular malformations. The most prominent cardiac defects in NS are pulmonary valve stenosis and hypertrophic cardiomyopathy. Gain-of-function mutations in the protein tyrosine phosphatase Shp2 have bee...

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Source

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Identifiers

PMID: 19017799
DOI: 10.1073/pnas.0806556105
PMCID: PMC2596231

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19017799-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Role of ERK1/2 signaling in congenital valve malformations in Noonan syndrome.PMID 19017799Read ↗

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