Article
Loss of Apela Peptide in Mice Causes Low Penetrance Embryonic Lethality and Defects in Early Mesodermal Derivatives.
Cell reports - 29 Aug 2017
Freyer Laina, Hsu Chih-Wei, Nowotschin Sonja, Pauli Andrea, Ishida Junji, Kuba Keiji, Fukamizu Akiyoshi, Schier Alexander F, Hoodless Pamela A, Dickinson Mary E, Hadjantonakis Anna-Katerina
Abstract excerpt
Apela (also known as Elabela, Ende, and Toddler) is a small signaling peptide that activates the G-protein-coupled receptor Aplnr to stimulate cell migration during zebrafish gastrulation. Here, using CRISPR/Cas9 to generate a null, reporter-expressing allele, we study the role of Apela in the developing mouse embryo. We found that loss of Apela results in low-penetrance cardiovascular defects that manifest after...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.