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Endothelial ERK signaling controls lymphatic fate specification

8 Feb 2013

Abstract excerpt

Lymphatic vessels are thought to arise from PROX1-positive endothelial cells (ECs) in the cardinal vein in response to induction of SOX18 expression; however, the molecular event responsible for increased SOX18 expression has not been established. We generated mice with endothelial-specific, inducible expression of an RAF1 gene with a gain-of-function mutation (RAF1(S259A)) that is associated with Noonan...

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PMID: 23391722
DOI: 10.1172/jci63034

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