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Cell line-dependent differentiation of induced pluripotent stem cells into cardiomyocytes in mice

14 Jun 2010

Abstract excerpt

AIMS: Mouse and human fibroblasts can be directly reprogrammed to pluripotency by the ectopic expression of four transcription factors (Oct3/4, Sox2, Klf4, and c-Myc) to yield induced pluripotent stem (iPS) cells. iPS cells can be generated even without the expression of c-Myc. The present study examined patterns of differentiation of mouse iPS cells into cardiomyocytes in three different cell lines reprogrammed...

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PMID: 20547733
DOI: 10.1093/cvr/cvq189

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