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Article

iPSC-derived cardiomyocytes reveal abnormal TGF-β signalling in left ventricular non-compaction cardiomyopathy.

Nature cell biology - 1 Oct 2016

Kodo Kazuki, Ong Sang-Ging, Jahanbani Fereshteh, Termglinchan Vittavat, Hirono Keiichi, InanlooRahatloo Kolsoum, Ebert Antje D, Shukla Praveen, Abilez Oscar J, Churko Jared M, Karakikes Ioannis, Jung Gwanghyun, Ichida Fukiko, Wu Sean M, Snyder Michael P, Bernstein Daniel, Wu Joseph C

Abstract excerpt

Left ventricular non-compaction (LVNC) is the third most prevalent cardiomyopathy in children and its pathogenesis has been associated with the developmental defect of the embryonic myocardium. We show that patient-specific induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) generated from LVNC patients carrying a mutation in the cardiac transcription factor TBX20 recapitulate a key aspect of the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27642787
DOI: 10.1038/ncb3411
PMCID: PMC5042877

Genes

TBX20
PRDM16

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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